Best Berberine Supplements of 2022

Best Berberine Supplements of 2022

Berberine is one of the most used products when it comes to traditional medicines. It has a long history of use in traditional Chinese medicine, Chinese culture, and Indian culture. It belongs to medicines called alkaloids, which are natural organic compounds that don’t contain nitrogen. Moreover, it includes only non-acidic components.

According to modern science, this supplement is excellent for helping those who have chronic illnesses. It can cause a significant reduction in blood sugar levels, helps with creating good gut bacteria, help you lose weight, does blood sugar, and has many more health benefits.

However, many companies pay for their Berberine product to be shown and promoted on the web while its ingredients and effectiveness may be unsafe or untested. We made our list of the best Berberine supplements of 2021 so that you can stop relying on false information and get to the best brands and products.

We will go on and look into each product more deeply and provide you with all of the necessary information so that you can make the best choice and you can buy the right supplement.

2022’s Best Berberine Supplements With Full Reviews

We will go through the vital information about the following best Berberine supplements:

  1. Berberine HCL – Overall Best Berberine Supplements for Blood Sugar
  2. Sunergetic Berberine – Premium Berberine for Diabetes
  3. Berberine Root Extract – Most Recommended for Lowering Blood Sugar Levels
  4. Berberine-500 – Affordable Berberine Dosage for Weight Loss
  5. Berberine Pure +   – Popular for Lowering Cholesterol

#1. Berberine HCL – Overall Best Berberine Supplements for Blood Sugar 


Berberine HCL, made by Bulk Supplements, is found in Goldenseal, Oregon Grape, Barberry, and Golden-Thread. It can be used orally, or it can be applied topically to the skin as well. It is designed to help with digestion problems as long as you keep a healthy diet and exercise.

You can get it in different sizes of 25 Grams (0.9 oz), 50 Grams (1.8 oz), 250 Grams (8.8 oz), 500 Grams (1.1 lbs), 1 Kilogram (2.2 lbs), 5 Kilograms (11 lbs), and 25 Kilograms (55 lbs).

You can take these pills as a dietary supplement. Take 500 mg once or twice a day or as directed by your PCP.


The brand ships its products from the United States. Domestic orders over $49 ship free. Shipments that are going outside their borders, they might be subject to customs duties and taxes that you will be responsible for. The company also advises you to double-check with your local customs office and check if the product is banned in your country.

Unopened products can be returned within 30 days from the invoice date for a full refund. Opened orders may be eligible for a partial refund. Shipping charges or any discount codes that you might have used will not be refunded.


  • Promotes heart, vision, and bone health
  • Supports liver function
  • Aids digestion
  • Helps maintain healthy glucose levels in already healthy people
  • Free U.S. shipping on orders over $49
  • 30-day return policy


  • May cause constipation or nausea

Customer Reviews 

According to product reviews, customers are completely satisfied with the product, and they rated the product as high quality. They will continue using the product in the future as they have experienced the health benefits of it.

=> Click here to avail the best offers on Berberine HCL 

#2. Sunergetic – Premium Berberine for Diabetes


Berberine Supplement has been used for many years by herbalists. Sunergetic Berberine is sourced from premiumBerberis aristata. The product is manufactured in an FDA-registered facility that adheres to Good Manufacturing Practices (GMP).

This product provides 600 mg Berberine HCL per capsule, which is more than most Berberine supplements on the market. If you would like a powerful dosage of Berberine this is the perfect product for you. You will get 1,200 mg of Berberine just from taking two capsules per day.

These capsules are convenient and easy to use since they are made to be easy to swallow and are entirely vegetarian.


The company offers free shipping on orders made over $40. They offer a 365-day refund policy on regular-priced items but not items that were on sale. Sunergetic will offer a replacement on any damaged products. You just need to send the company an email, and it will provide you with further information. The customer support will respond to your email, and you will get your product right away.

And if by any chance you are not satisfied with this product, you can always email them, and they will respond in order for you to find a solution to your problem, and they will let you know what your next step would be.


  • Premium quality
  • Vegetarian-friendly
  • Supports blood sugar levels
  • Helps with cardiovascular health
  • Free shipping on orders over $40
  • 365-day return policy


  • Not intended for long-term use.

Customer Reviews

Many customers stated that Sunergetic’s Berberine supplement is easy to use and helps with their overall health. In addition, these pills help them with their cardiovascular problems, which is a great plus for this product.

Some customers stated that they would recommend this product to everyone they know who has the same kind of symptoms or problems with their health. There are no noticed problems with the shipping or damaged products.

=> Click here to avail the best offers on Sunergetic

#3. Berberine Root Extract – Most Recommended for Lowering Blood Sugar Levels


Berberine Root Extract, Advanced Formula is manufactured in the United States in Salt Lake City, Utah. It is manufactured by the famous company Solaray which has existed for more than four decades, and its products are distributed in over 60 countries.

The product formula can help you in many ways, starting with supporting your active lifestyle, your metabolism, and your overall wellness. So if you have any health issues, this product will get you back on track with your healthy lifestyle.


This product is additionally suitable for those who are following the ketogenic diet because berberine can play a great role in supporting their metabolic support concerning ketones, glucose storage, and fatty acids.  That’s why Berberine is made to support your AMPK activation, which can be of great benefit for everyone, not only for those who follow the ketogenic diet.

Berberine Root Extract, Advanced formula, is tested in a lab and is non-GMO and vegan-friendly.

The company offers free delivery on orders that are over $50. They provide international shipping in more than 185+ countries. Besides, if for any reason you are not satisfied with the Berberine Root Extract, Advanced Formula, you can request a refund or replacement of the product within 60 days of your purchase.


  • Vegan-friendly
  • Non-GMO
  • Helps blood sugar control
  • Improves cardiovascular health, arthritis, and overall wellness
  • May reduce symptoms associated with menstrual problems
  • Free shipping on orders over $49
  • 60-day return policy


  • May cause constipation or an upset stomach

Customers Reviews 

Most customers reported being satisfied with just their first bottle of pills. Many female customers are delighted with the product since it helped them with their menstrual cycles and immediately experienced stabilizing effects of Berberine.

Some of the customers also used the product to help them with H. Pylori, and the pills helped quickly. They also stated that they had not used any antibiotic to help them, only the Berberine Root Extract, Advanced Formula.

Moreover, many customers gave positive feedback because this product helped them regulate their blood pressure.

=> Click here to avail the best offers on Berberine Root Extract

#4. Berberine-500 – Affordable Berberine Dosage for Weight Loss


Berberine-500 is produced by the reputable brand Thorne. This product is a powerful botanical supplement that can help with your heart health and immune system. It may help users maintain a healthy respiratory tract, mucus membranes, and GI system. In turn, a supported GI system will produce beneficial bacteria in the gut and support weight loss and management.

Thorne’s Berberine-500 is made from natural ingredients and no added flavors, colors, or sweeteners. Other ingredients include Calcium Laurate and a Hypromellose capsule.


The product is completely dairy-free, soy-free, and gluten-free. The company offers same business day shipping as long as you place your order any time before 12:00 pm Eastern time, Monday through Friday. Unfortunately, there is no weekend service.

Furthermore, a great feature is that their packaging is made of recycled materials.

Healthcare providers can expect to receive orders within one or two business days, and patients can expect to receive their order within two to ten business days.

Thorne offers international shipping, and it usually takes around four weeks for delivery outside the U.S.


  • Supports heart and gut health
  • Improves metabolism
  • May aid weight loss
  • Maintains healthy respiratory tract mucus membranes
  • Free shipping on U.S. orders
  • 60-day money-back guarantee


  • Does not ship to P.O. boxes

Customer Reviews

Customers state that this product helped to lower their cholesterol. Moreover, this product reportedly helped diabetic patients to lower their blood sugar levels without any exercise or activities.

There are many happy buyers who lost a lot of unnecessary fat cells just by using the product and doing nothing else. As they state, this product has changed their lives for the better.  Overall this product is great, and it helps in many different ways so you can stay healthy and active. All of the customers received their product just on time, and there were no delays.

=> Click here to avail the best offers on Berberine-500

#5. Berberine Pure +  – Popular for Lowering Cholesterol


Nuzena’s Berberine Pure + is made in FDA-regulated facilities from all-natural ingredients. This supplement is suitable for both men and women. It can help with high cholesterol, regulate blood sugar levels and metabolism.

These pills help you activate an enzyme inside your cells which is called AMP-activated protein kinase (AMPK). This enzyme plays a significant role in your body since it regulates your metabolism and is found in the cells of various organs. The AMPK can be found in the brain, heart, liver, and kidneys.

According to a recent study, Berberine works by inhibiting an enzyme called PCSK9, which removes LDL from the bloodstream. This process maintains the healthy cholesterol in your body. Furthermore, it can break down the carbohydrates in the gut. This can help the gut to increase its good bacteria.


Orders process within two to three business days. USPS Standard shipping should arrive within three to five business days. International orders typically arrive within seven to ten business days. All shipping information and confirmation is sent to your email. Nuzena also partners with Amazon Prime, so their product can be purchased through Prime to take advantage of their expedited shipping. Orders can be paid for using PayPal or your VISA, Mastercard, Discover, or American Express card.

One of their highlights is that if you are an influencer and use social media like Facebook, Instagram, and Twitter and have an audience interested in a healthy lifestyle and fitness, you can easily promote the product as an affiliate. You just need to contact Nuzena and they will provide you with more content on how you can start working with them.

In case the order is at default, or there is some kind of problem, the company can easily replace the order and send you a new product. You can easily return the damaged product since it will give you the information in the package that you will receive. The best part is that all this is free of charge.


  • Clinically proven ingredients
  • Non-GMO
  • Gluten-Free
  • Supports heart health
  • Improves metabolism and lipid bundles


  • Results may take 90 days to manifest

Customer Reviews 

According to our research, there is 99% positive feedback regarding this product.

Most users have experienced increased energy which helped them to complete their daily tasks. The product can also help you if you are experiencing brain fog, which is a great plus.

Users love this product, and they state that they will recommend the product to their friends and family members.

The customer’s packaging arrived right on time with no delays and no damaged products. Nuzena’s customer support team was also lauded for their fast and helpful responses.

=> Click here to avail the best offers on Berberine Pure +

Berberine Supplements 

The Berberine Products in this article, Berberine HCL, Sunergetic Berberine, Solaray Berberine, Berberine-500, and Berberine Pure + are entirely safe to use and may induce different health benefits.

This supplement may cause weight loss, reduce blood sugar levels, lower cholesterol, and lower your risk of heart disease. There is also some evidence to suggest it may reduce depression.

We have done complete research, and according to our research standards, we will provide you with entire information about each product.

Buying Guide

We have checked every brand that contains the Berberine supplement and cut our list to the best 5 Berberine supplement brands, and we checked each brand for the following, and this is what you should consider before buying the product.

  • Effectiveness of the Berberine pills

This product has been used in China and India for many years to treat different diseases. Currently, it is being used by thousands of satisfied customers.

They are overall very much effective, and they have many positive benefits. They can help you with your overall health. Most importantly, they can help you reduce high blood pressure, reduce brain fog, and improve your metabolism.

  • Efficient in treating PCOS using Berberine pills

Currently, research is done to see if Berberine can be a good treatment for polycystic ovarian syndrome patients.

It has been observed that it is effective since it helps with high blood pressure, high cholesterol, overweight, and diabetes. All PCOS patients are experiencing all of these mentioned symptoms because of the change in their hormones and metabolism.

  • Efficient in treating Cancer using Berberine pills

According to the research done in cancer cell laboratories, it has been proven that Berberine can help with ovarian cancer, prostate cancer, colorectal cancer, lung cancer, liver cancer, and cervical cancer.

It has been proven that they can reduce the risk of getting cancer and also reduce all of the symptoms that cancer can cause.

  • Ingredients of the Berberine pills

The Berberine pills are all made of natural compounds. The Berberine is found in some trees like, for example, Oregon Grape, Phellodendron. Goldenseal, European barberry, and Turmeric Tree as well. It has a yellow color, and it has a bitter taste.

  • Clinical tests and researches done on Berberine pills

There is some research done, and it is proven that the pills are all safe to consume. Sometimes they can also act as a prescription drug, so you should see your PCP before taking this supplement.

According to the Association for the Advancement of Restorative Medicine, Berberine can reduce blood glucose and insulin resistance levels in patients who are suffering from type 2 Diabetes.

  • Adverse side effects and their severity 

According to the research that multiple research centers did, it is proven that there are no side effects of using Berberine products.

Keep in mind that the Berberine products can lower your blood sugar levels, so if you already have low blood sugar make sure you contact your doctor before taking any of the Berberine pills.

  • Interaction with other medicines 

According to the researchers, taking Berberine with some medication that can slow clotting might increase your chances of bruising.

But it has been shown that they do not interact with any other prescribed drugs.

In case you are taking different medications, and you have multiple heart conditions or maybe problems with your sugar level, make sure you contact your doctor before taking the supplement.

  • Harmful ingredients

Since these products are made out of organic substances, it is completely safe to use them, and they have no harmful ingredients.

  • Customer’s reviews

We have done the research, and we show that the customers are extremely satisfied by using the products.

Overall there is only positive feedback, and there are more than 1000 satisfied customers who have been using the pills for months and years.

Furthermore, they are completely satisfied by the consumer care support for each individual brand of the above-mentioned Berberine products.

  • Dosage & Usage

Each product has its instructions for use that are written on the bottle.

  1. Berberine HCL: You can take 500 mg once or twice daily or as instructed by your physician.
  2. Sunergetic Berberine: You can take two capsules daily or as instructed by your physician.
  3. Solaray Berberine: You can take one Vegcup daily with your meal or with a glass of water, or as instructed by your physician.
  4. Berberine-500: You can take two capsules daily or as instructed by your physician.
  5. Nuzena Berberine+: You can take 2 capsules a day. The best time to take them is before your meals or as instructed by your physician.
  • Prescription 

There is no need for a prescription in order for you to buy the Berberine pills. You can get any of these pills over the counter, or you can order them online.

Make sure you consult with your PCP or a healthcare worker before taking any Berberine supplements. And also, make sure you discuss your current and past medical history with your current PCP.

Frequently Asked Questions about Berberine Pills

Q. Who can not take the Berberine pills?

If you are pregnant, it is mostly unsafe to use Berberine by mouth or in any other form. According to some studies, the Berberine can cross the placenta, and it might cause some harm to the fetus. The results have shown that most likely a type of brain damage called Kernicterus can develop in newborn babies that were exposed to Berberine.

If you are breastfeeding, it is not safe to take Berberine since it can be transferred to the infant, and it might cause some harm as the above-mentioned brain damage.

It is not safe for newborns or infants since it can cause brain damage. And newborns who have a health condition called Jaundice.

Jaundice is a severe condition that can make the skin, whites of the eyes, and mucous membranes turn yellow because of high levels of bilirubin. Also, if you have this condition and you start taking the product, it might lead to hepatitis and tumors.

Q. How long should I take Berberine pills before I see an effect?

If you want to see any results, you should take the Berberine pills around 3 or 4 weeks before noticing any changes.

According to the customer reviews, it usually takes three weeks for any positive effect to be noticed. Moreover, it depends on what type of health conditions you have and your age and current health.

Q.  What happens if I take too many Berberine pills?

According to the studies, there are no severe side effects if you use too much berberine. This supplement can only help you regulate your blood sugar, hormone levels, and possible heart diseases. It can also treat some metabolic problems, including diabetes and obesity. Overall you can only expect great results, and there is no risk of taking too much Berberine.

Q. When is the best time to take Berberine pills to gain better berberine benefits?

You should follow the instructions written on the package. All of the reviewed products have information and instructions on how and when to take them.

The researchers usually recommend Berberine to be taken once or twice a day with your regular meals or shortly after your meals. This dosage is recommended so the Berberine can work on reducing your blood sugar levels.

When taking Berberine capsules, it is not recommended that you take the two or three capsules with a single meal since it won’t be effective, and you won’t see any results. And another disadvantage of taking more than one pill at the same time is because it can cause some Gastro problems, such as bloating.

Before using any of the Berberine pills, make sure you contact your PCP.

Q. Can Berberine pills help with Polycystic Ovary syndrome? 

PCOS is a condition that occurs when a female has a high level of some male hormones. The syndrome causes hormonal and also metabolic imbalance. This syndrome usually leads to infertility and even more severe health conditions like high cholesterol, high blood pressure, and getting overweight.

Doctors usually recommend women who have PCOS to take the Berberine supplement since it has similar effects as some other prescribed pharmaceutical drug used to treat PCOS. Additionally, according to some studies, Berberine pills can be a good treatment for PCOS!

Q. Can Berberine pills help Cancer patients? 

Sin ce Berberine can make some changes in the molecular cells, it has been proven that it can help fight cancer.  This is one of the best benefits of Berberine pills.

According to the research done in cancer cell laboratories, it has been proven that Berberine can help with ovarian cancer, prostate cancer, colorectal cancer, lung cancer, liver cancer, and cervical cancer.

Another study shows that Berberine pills can help treat cancer by interfering with its progress and its cycle. As well, it plays a role in killing cancer cells.

Keep in mind that this research is only done at special cancer cell laboratories, and they are not done on actual people who are diagnosed with cancer.

Q. Is Berberine effective in the treatment of Nonalcoholic Fatty Liver Disease?

Nonalcoholic fatty liver disease is actually a metabolic stress-induced liver injury. This injury is closely related to insulin resistance. This disease has a specter or branches of liver diseases.

According to an analysis done on more than 500 people with fatty liver disease, the final results were positive. So it was concluded that the patients with the nonalcoholic fatty liver disease could use berberine, and it can help them to control the disease and maybe even cure it.

Q. Which is better, Berberine supplement or Metformin?

Metformin is a blood glucose-lowering agent, and it is beneficial for patients who have impaired glucose regulation.

According to many studies, it is proven that the Berberine supplements are much better than the Metformin medication since it is an all-natural remedy and has more benefits than taking the Metformin medication.

The Berberine supplements work better since they are faster AMPK activators, which means it can draw glucose and blood lipids into a cell. That allows them to be used as energy.

However, Berberine is easier to use than Metformin medication. But don’t forget to consult with a healthcare provider or your PCP before using any Berberine product or if you already have a medical history.


In conclusion, all of the Berberine Products that we reviewed, Berberine HCL, Synergetic Berberine, Solaray, Berberine-500, and Berberine Pure +, are all-natural remedies that can help you in many ways with your health.

Overall the Berberine Products can help you with high blood pressure, overall wellness, arthritis, cardiovascular health and helps cancer patients and women with Polycystic ovary syndrome or metabolic syndrome.

We hope that this article provided you with the best information you can get out there on the web regarding the best Berberine pills. We have done the research, and we hope that we can help you get the motivation today to buy some of the reviewed Berberine pill products that can provide you with great results and help you in the best ways possible.

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